Endocrine Abstracts

Glucocorticoids (GCs) are the most commonly used anti-inflammatory and immunosuppressive drugs. Their efficacy seems to be caused by the interference of the ligand-activated glucocorticoid receptor (GR) with many pro-inflammatory pathways via different mechanisms. The ubiquitous expression of the GR is a prerequisite of this efficacy. The main draw back of GCs, however, is due to their potential to induce undesired effects, in particular upon high doses and prolonged usage. In...